Endocrine Abstracts

Introduction: Erectile dysfunction (ED) is considered an early surrogate marker of silent, or even overt, cardiovascular diseases (CVD). However, epidemiological studies take into account only sexual intercourse-related erections. Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are lacking.Aim: To evaluate the clinical correlates of impaired mas...

Introduction: Measurement of testis volume (TV) is a reliable clinical procedure that predicts reproductive fitness. However, the role of TV in overall and cardiovascular (CV) fitness has never been studied.Aim: The study aims to analyze the clinical correlates of TV in patients with sexual dysfunction (SD) and to verify the value of this parameter and its determinants (i.e., luteinizing hormone (LH) levels) in predicting major adverse CV events (MACE).<...

Introduction: Sexual dysfunctions (SD) are dictated by predisposing, precipitating, maintaining, and contextual factors, the latter of which can help sexual problems to emerge. Even if the lack of sexual privacy is one of the most common contextual issues, it has not been extensively studied.Aim: Investigation of sexual privacy in a large sample of men consulting for SD.Methods: A consecutive series of 3736 men, attending the Outpa...

Introduction: The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, which assesses, beside the organic (Scale1) and intra-psychic (Scale 3) domains, also the relation one (Scale 2). We previously established a pathological threshold for SIEDY Scale 1 and 3.Aim: To identify a pathological threshold of SIEDY Scale 2.Metho...

Introduction: The disorders of orgasm/ejaculation include premature ejaculation, delayed ejaculation and perceived ejaculate volume reduction (PEVR). To explore the specific associations of PEVR in subjects with erectile dysfunction (ED).Methods: A consecutive series of 3141 subjects (mean age 51.6±13.1 years old) was studied. Among these, 71 have been excluded because they underwent prostate surgery. Different clinical and biochemical factors were ...

Introduction: We previously reported that in subjects consulting for sexual dysfunction lower PRL plasma levels were associated with worse lipid and glycemic profile, as well as with a higher prevalence of metabolic syndrome and arteriogenic erectile dysfunction (ED). To assess possible associations between PRL levels and incident major cardiovascular events (MACE) in subjects with ED.Methods: This is an observational prospective cohort study evaluating ...

Introduction: The relationship between alcohol consumption and erectile function is still not completely clarified. Aims of the present study are to explore a number of biological and clinical correlates of alcohol consumption in a sample of men consulting for sexual dysfunction, and to verify possible associations with the incidence of major adverse cardiovascular events (MACEs).Methods: A consecutive series of 1956 (mean age 55±11.9 years old) att...

Introduction: Previous clinical studies on effect of statins treatment on testosterone levels have produced mixed results. The aim of the present study is to evaluate the association between statin therapy and hormonal parameters in a large series of subjects seeking medical care at our Unit for ED.Methods: A consecutive series of 3484 (mean age 51.6±13.1 years) patients with ED was studied.Several hormonal and biochemical par...

Introduction: Although it is well established that all the aspects of male reproduction are hormonally regulated, the endocrine control of the ejaculatory reflex is still not completely clarified. Sex steroids, thyroid and pituitary hormones (oxytocin and prolactin) have been proposed to control the ejaculatory process at various levels, however, only a few reports are currently available. The aim of the present study is to evaluate the contribution of testosterone, TSH and pr...

Objectives: BPH is characterised by prostate inflammation, which frequently occurs in men with metabolic syndrome (MetS). MetS is often associated with low testosterone (T). Recent evidence shows that low, rather than high, T is associated with BPH/lower urinary tract symptoms (LUTS). To evaluate if T replacement therapy (TRT) for 6 months in BPH men with MetS and low T, is able to improve LUTS and prostate inflammation.Methods: 120 men in waiting list f...